Recently, Yang Liangbao, a researcher at Hefei Institute of Intelligent Mechanics, Hefei Institute of Material Science, Chinese Academy of Sciences, etc., built a “pluggable†SERS sensor based on acupuncture needles to achieve in-situ detection of multiphase systems. The sensor is expected to be used in acupuncture mechanisms. Research. The relevant results are published in Analytical Chemistry.
Traditional acupuncture has a long history and is a feature and advantage of medical science in China, and has a positive impact on the development of medical science in the world. However, acupuncture does not give a clear basis for modern science. The mechanism of acupuncture is not clear, which limits the development and promotion of acupuncture to a large extent. It is also the most important reason why acupuncture is not widely recognized and accepted at home and abroad. In recent years, surface-enhanced Raman spectroscopy (SERS) technology has attracted much attention due to its ability to perform non-destructive and highly sensitive fingerprint recognition detection, and has been widely used in various basic research fields. It is unclear whether SERS technology can be used to study traditional acupuncture mechanisms.
Inspired by traditional acupuncture and silver needles, the researchers modified the PVP-wrapped gold nanoparticles on the surface of the acupuncture silver needle to construct a “pluggable†SERS sensor. As a binder, PVP can directly modify the gold nanoparticles on the silver needle, and due to the steric hindrance of PVP on the surface of the gold nanoparticles, the gold nanoparticles on the surface of the silver needle tend to be densely arranged, which helps to form more A number of "hot spots" to increase the sensitivity of "pluggable" SERS sensors. In addition, the electromagnetic field coupling effect between gold nanoparticles and between gold nanoparticles and silver needles helps to further enhance the Raman signal. Compared with the traditional SERS sensor, the “pluggable†SERS sensor is easier to reach inside the sample, and the different depths of the sample can be obtained by taking the spot detection at different positions on the surface of the needle. The researchers placed a "pluggable" SERS sensor in a water-oil two-phase system, taking point detection from the aqueous and oil phases, respectively, to obtain molecular information in different phases. This "pluggable" SERS sensor is expected to be used in biological living samples, especially for the study of traditional acupuncture mechanisms.
The research work has been supported by major new drug creation technology majors and the National Natural Science Foundation.
Construction and detection of "pluggable" SERS sensor
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