With the increase of social pressure and the acceleration of life rhythm, more and more people are facing the problem of hair loss. Recently, researchers have found that stem cells that produce fat precursor cells play an important role in the fat growth and hair regeneration. This cell produces a molecule called PDGF (platelet-derived growth factor) that restores mouse hair growth.
Platelet derived growth factor (PDGF) is a basic protein stored in platelet alpha particles. It is a low molecular weight mitogen.
It can stimulate various cells such as fibroblasts, glial cells and smooth muscle cells that are arrested in G0/G1 phase to enter the division and proliferation cycle. The platelet-derived growth factor PDGF was discovered in 1974 as a peptide regulator that stimulates the growth of tissue cells such as connective tissue. It is named because it is derived from platelets. It is present in the alpha particles of platelets under normal physiological conditions, when blood coagulates. Released from activated platelets and activated, with biological activity that stimulates specific cell chemotaxis and promotes specific cell growth.
In addition, macrophages, vascular smooth muscle cells, fibroblasts, endothelial cells, embryonic stem cells, and the like can also synthesize and release PDGF when the tissue is damaged. When the liver is damaged, macrophages, platelets, infiltrating inflammatory cells, damaged endothelial cells, and activated hepatic stellate cells can secrete PDGF. Play a role in autocrine and paracrine. The bound PDGF is a thermostable glycoprotein with a molecular weight of 30KD, which is a dimer composed of two polypeptide chains A and B linked by disulfide bonds.
The platelet-derived growth factor family includes platelet growth factor (PDGF) and vascular endothelial cell factor (VEGF). Each growth factor can be produced by a variety of cells, and its receptors are all tyrosine kinase (RTK) type receptors. Platelet-derived growth factor family members include: PDGFA, PDGFB, PDGFC, PDGFD, Placental growth factor (PGF), and vascular endothelial growth factor VEGF, VEGF41, VEGFB, VEGFC, FIGF (VEGFD), and the like.
The common platelet-derived factor PDGF is a homo- or heterodimer formed by the disulfide linkage of two polypeptide chains, which makes PDGF have multiple forms of dimeric structure, namely PDGF-AA, PDGF-BB, PDGF. - AB, PDGF-CC and PDGF-DD. [2] wherein the PDGF-A chain has a molecular weight of 16 KD and the PDGF-B chain has a molecular weight of 14 KD. The A and B chain genes are located on chromosomes 7 and 22, respectively. The so-called PDGFI, PDGF-AA, has a molecular weight of 31KD and contains 7% sugar, PDGFII, PDGF-BB, molecular weight of 28KD, and contains 4% sugar, both of which are composed of two highly homologous A and B chains. In vivo mononuclear/macrophages are cells that primarily synthesize PDGF.
Platelet-derived growth factor elisa kit (http://) features: high accuracy, high sensitivity, specificity, short detection time, easy to operate. Please according to use instruction strictly, The test result determination must take the microtiter plate reader as a standard.
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